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What is PEXEVA?

PEXEVA is an antidepressant in the drug group call selective serotonin reuptake inhibitors (SSRIs). SSRIs are a group of drugs that act to balance the activity of serotonin in the brain. Serotonin is a chemical with many actions in the body; one of the functions of serotonin in the brain is to modify mood and behavior.

In people with depression, PEXEVA can help resolve symptoms like sadness, low energy, sleep difficulty, irritability, and despair. PEXEVA is indicated for depression, obsessive-compulsive disorder, and panic disorder. PEXEVA contains paroxetine, which has been prescribed for millions of people.

PEXEVA is not addicting and is not a controlled substance. There is no generic alternative of PEXEVA, so pharmacists cannot switch your PEXEVA prescriptions.


If your refill tablets do not look like this, consult your physician.

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Important Safety Information

Suicidal thoughts or behavior and antidepressant drugs
Short-term studies have shown that antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults. When deciding to use PEXEVA® or any other antidepressant in these age groups, people must balance the risk with the potential benefit to the patient. Short-term studies did not show an increased risk of suicidality with antidepressants compared to placebo in adults beyond age 24; the risk decreased in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored by their doctor and watched closely to see if their condition worsens, if they have suicidal thoughts or behavior or if they exhibit any unusual changes in behavior. Families and caregivers need to understand that they should watch the patient closely and tell the doctor if they have any concerns. PEXEVA® is not approved for use in pediatric patients.


The most common side effects that have been reported with PEXEVA® include nausea, dry mouth, constipation, decreased appetite, infection, drowsiness, tremor, sweating, muscle weakness, trouble sleeping, abnormal ejaculation, impotence and other male genital disorders, and female genital disorders.

Please see Important Safety Information, including Black Boxed Warning. Please see accompanying full Prescribing Information including use in Pregnancy. (See WARNINGS-Clinical Worsening and Suicide Risk and Usage in Pregnancy: Teratogenic and Nonteratogenic Effects).

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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